Aula Magna, Polo Didattico di Rimini, Via Angherà 22, Rimini, Italy


Chairman's Invitation

On behalf of the Scientific and Organizing Committees it is my pleasure to invite you to the 13th Summer Course on Pharmaceutical Analysis that will take place 21-23 September, 2008 at the Aula Magna, Polo Scientifico e Didattico di Rimini, Alma Mater Studiorum Università di Bologna, Via Angherà 22, Rimini, Italy.

Since 2008 the Summer Course on Pharmaceutical Analysis (SCPA) will change its structure and will cover a three-year program on the most advanced analytical methodologies involved into the launch of new drugs, starting from the discovery phase (hit identification, structure properties relationship), through drug development (lead optimisation, ADMET studies, biomarkers identification) ending with formulation quality control and validation. New cycles will follow in which the most recent analytical topics in the specific phase will be introduced.

In 2008 the SCPA first year program is focused on ‘ADVANCED ANALYTICAL METHODOLOGIES IN DRUG DISCOVERY’. In particular, the cutting-edge analytical approaches in pharmaceutical profiling (SPR) and hit identification are examined.
Pharmaceutical profiling is an emerging strategy in drug discovery and represents an enhancement of the SAR paradigm because properties have a major effect on in vitro and in vivo pharmacology. Drug discovery scientists can understand and control more of the variables that affect their experiments, to achieve increased success. Profiling data assist the diagnosis of compound performance at various barriers as well as the prioritisation and optimisation and alerts research teams to factors that affect development attrition. Properties can be improved via structural modifications, and best candidate can be selected for advancement.
High throughput assays lessons and tutorials are scheduled for physicochemical properties determination for SPR (structure-property relationship). HTS methods for the determination and optimization of physico-chemical parameters such as integrity, solubility, permeability, lipophilicity, pKa, bioavailability, stability, etc. are taught by eminent scientists in the field. Lessons and tutorials for purpose methodologies to determine solubility, aggregation and aggregate dimensions (dynamic light scattering, DLS) and barrier-assay model are scheduled.
Second day faces analytical tools in supporting the discovery of new drugs, which require miniaturization to facilitate the screening of classes of compounds for their binding to the target protein for hit identification (NMR, optical biosensor), but also a deeper characterization of the mechanisms involved in the molecular recognition processes (Circular Dichroism), for probing structure and folding of target protein and their changes upon binding with ligands.
Some speakers are going to organize tutorials in the informatic room to simulate experiments and determine parameters.
The course is open to a maximum of 80 students and is held in English language. By attending the 13th SCPA, PhD students will be able to acquire 3 CFU (credits).

Vincenza Andrisano
Chairman 13th SCPA

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On behalf of:

13th SCPA, Aula Magna, Polo Scientifico e didattico di Rimini
Alma Mater Studiorum Università di Bologna, Via Angherà 22, Rimini, Italy