SSPA, SUMMER SCHOOL ON PHARMACEUTICAL ANALYSIS

The Summer School on Pharmaceutical Analysis (SSPA) is based on a three-year program on the most advanced analytical methodologies involved in the launch of new drugs. The SSPA 2011 edition (Cycle II, 1st year) was focused on “Advanced Analytical Methodologies in Drug Discovery” for characterizing ligand-target interaction through bioaffinity chromatography with immobilized target proteins, NMR, MS techniques, luminescence and FRET methods for ligand screening and hit selection.
The ultimate goal of a drug discovery program is to generate a candidate drug compound that, besides being active and selective in vitro on the isolated target, is safe and efficacious in humans. In order to develop such a compound, many criteria including affinity, activity, selectivity, physico-chemical properties, and pharmacokinetics must be optimized. The definition of these criteria involves the availability and knowledge of appropriate bio-analytical methodologies.
Therefore, following the SSPA 2011, the SSPA 2012 edition (II year) is oriented on ‘ADVANCED ANALYTICAL METHODOLOGIES IN DRUG DEVELOPMENT’.
Specifically, the main topics that will be approached during the school are:

i) Pharmacokinetic parameters in drug development. The following questions will be addressed: how can the in vivo behavior of a compound under development be determined? What are its clearance, half life, distribution and metabolic rate? Which methodologies can be applied to determine these parameters?
ii) In silico prediction and in vitro determination of ADMET properties. The following questions will addressed: how can we predict physico-chemical (PC) and principal ADME (absorption, distribution, metabolism, and excretion) processes? How can these in silico parameters be integrated with in vitro pharmacokinetic (PK) data? Which are the most suitable methodologies to in vitro determine drug metabolism and distribution?
iii) In vivo determination of ADMET properties: sample preparation. In in vivo drug metabolism and pharmacokinetic studies biological samples need to be analyzed. The following question will be addressed: what are the most efficacious, reliable, accurate procedures for sample preparation prior to the analysis?
iv) Biomarkers in drug development. The following questions will be addressed: which methodologies can be used for rapid and reliable assessment of markers of efficiency and security of drug under development? Which are the most appropriate analytical techniques to obtain the fingerprints in a non-target metabolomic approach? How multivariate data analysis can reveal a good group clustering and permit the putative assignment of compounds statistically significant in the classification?

The tutorial sessions will focus on practical examples and general solutions to common problems. The use of LC/MS, GC/MS, and NMR will be described, such as method development for metabolic products by LC-tandem MS and its application in mammalian cells and in humans. The potential and limitations of these techniques together with future perspectives will be also discussed.

The course is open to a maximum of 80 students and is held in English language.If you already participated at SSPA previous edition(s), do not miss this opportunity to enlarge your knowledge on the most advanced bio-analytical methodologies in drug development by attending SSPA 2012!

Vincenza Andrisano
SSPA Director

 

 

   

DEADLINE FOR EARLY REGISTRATION HAS BEEN EXTENDED TO APRIL 30, 2012

APRIL 13, 2012: DEADLINE FOR Ph.D ABSTRACT SUBMISSION


BEST PhD ORAL PRESENTATION AWARD

Awards for the best two oral presentations given by PhD students will be selected by a scientific committee. [details]

SSPA 2012 sponsors

SSPA 2012
Aula Magna, Polo Scientifico e Didattico di Rimini
via Angherà 22,
Rimini, Italy

Under the auspices of:
 
Copyright © 2011 Department of Pharmaceutical Sciences